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CLINICAL TRIAL REFERENCES

BEAUTY FROM WITHIN

  • Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis, Subject Area:  Dermatology ,  Pharmacology, E.Proksch; M.Schunck; V. Zague; D. Segger; J. Degwert; S. Oesser, Skin Pharmacol Physiol (2014) 27 (3): 113–119.
  • Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. Authors: Michael Schunck, Vivian Zague, Steffen Oesser, and Ehrhardt Proksch. Publication: Journal of Medicinal Food. https://doi.org/10.1089/jmf.2015.0022
  • Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser  S  (2017)  Oral supplementation  with  specific bioactive  collagen  peptides  improves  nail  growth and reduces  symptoms  of  brittle  nails.  J  Cosmet  Dermatol 16:520–526
  • Campos MP et al. An oral supplementation based on hydrolyzed collagen and vitamins improves skin elasticity and dermis echogenicity: a clinical placebo controlled study. Clinical Pharmacology and; Biopharmaceutics 2015; 4: 142.
  • Rawlings AV. Ethnic skin types: are there differences in skin structure and function? Int J Cosmet Sci 2006; 28: 81-95.
  • Hillebrand GG et al. K. The age-dependent changes in skin condition in African Americans, Asian Indians, Caucasians, East Asians, and Latinos. IFSCC Mag 2001; 4: 259-266.
  • Matsumoto H et al. Clinical effects of fish type I collagen hydrolysate on skin properties. ITE Letters on Batteries, New Technologies and Medicine 2006; 7: 386-390.
  • Ohara H et al. Improvement in the moisture content of the stratum corneum following 4 weeks of collagen hydrolysate ingestion. Food Science and Technology Research 2009; 56: 137-145.
  • Inoue N et al. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomized, double-blind, placebo-controlled clinical study. J Sci Food Agric 2016; 96: 40 77-81.
  • Rodríguez MIA et al. Collagen: A review on its sources and potential cosmetic applications. J Cosmet Dermatol 2017; 17: 20-26.
  • Camacho-Bragado GA et al. Understanding breakage in curly hair. British J Dermatol 2015; 173: 10-16

SKIN, HAIR and NAILS

  • Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study Proksch E., Segger D., Degwert J., Schunck M., Zague V., Oesser S. Skin Pharmacol Physiology, August 2013
  • Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis Proksch E., Schunck M., Zague V., Segger D., Degwert J., Oesser S. Skin Pharmacol Physiology, December 2013
  • JOURNAL OF MEDICINAL FOOD, J Med Food 00 (0) 2015, 1–9, DOI: 10.1089/jmf.2015.0022, Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology Michael Schunck, 1 Vivian Zague, 2 Steffen Oesser, 1 Ehrhardt Proksch, 3
  • One-Way ANOVA, Fischer post-test, publication pending
  • Slowing down the clock with collagen peptides. Cosmetics Business white paper, January 2021 issue
  • Asserin J, Lati E, Shioya T, Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015 Dec;14(4):291-301. doi: 10.1111/jocd.12174. Epub 2015 Sep 12. PMID: 26362110
  • Bianchi et al. Evaluation of the Efficacy of a Hydrolyzed Collagen Supplement for Improving Skin
  • Moisturization, Smoothness, and Wrinkles. J Clin Aesthet Dermatol. 2022;15(3):48-52. Epub 2022/03/29. PubMed PMID: 35342502; PubMed Central PMCID: PMCPMC8944283.
  • Turner et al. Hair and Aging. Skinmed. 2016;14(5):338-43. Epub 2016/11/23. PubMed PMID:27871344.
  • Asserin et al. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo controlled clinical trials. J Cosmet Dermatol. 2015;14(4):291-301. Epub 2015/09/13. PubMed PMID: 26362110. doi: 10.1111/jocd.12174.
  • Vleminckx et al. Rousselot clinical data
  • Kuninty et al. Rousselot clinical data
  • Purba et al. Human epithelial hair follicle stem cells and their progeny: current state of knowledge, the widening gap in translational research and future challenges. Bioessays. 2014 May;36(5):513-25. Epub 2014 Mar 25. PMID: 24665045. doi: 10.1002/bies.201300166.
  • Pappelbaum et al. Revealing novel insights on how oral supplementation with collagen peptides may prevent hair loss: Lessons from the human hair follicle organ culture. Journal of Functional Foods 2024, 116, 106124. doi.org:10.1016/j.jff.2024.106124

BODY REFERENCES

  • Zdzieblik et al. 2015, 2017, 2021,  Jendricke et al. 2019, Kirmse et al. 2019, Oertzen Hagemann et al. 2019, Centner et al. (2022).
  • Zdzieblik et al. (2017). Effect of specific collagen peptides with various dosages on body composition in untrained men.
  • Zdzieblik, D. et al Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial, doi: 10.1017/80007114515002810, British Journal of Nutrition, 2015 3 Unpublished data 2015 , publication pending.
  • Tofas, T., et al., Pliometric Exercise Increases Serum Indices of Muscle Damage and Collagen Breakdown. The Journal of Strength and Conditioning Research, 2008. 22(2): p. 490-496.
  • Csapo, R., M. Gumpenberger, and B. Wessner, Skeletal Muscle Extracellular Matrix – What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review. Frontiers in Physiology, 2020.
  • Daneault, A., et al., Biological effect of hydrolyzed collagen on bone metabolism. Crit Rev Food Sci Nutr, 2017. 57(9): p. 1922-1937.
  • Asserin, J., et al., The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol, 2015. 14(4): p.291-301.
  • Clifford, T., et al., The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial. Amino Acids, 2019. 51(4): p. 691-704.
  • Gratwicke, M., et al., Nutritional Interventions to Improve Sleep in Team-Sport Athletes: A Narrative Review. Nutrients, 2021. 13(1586).
  • Thomas, C. et al., Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints. Accepted for publication in European Journal of Nutrition.
  • Yamadera, W., et al., Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms, 2007. 5(2): p. 126-131.
  • Taylor, G., et al., The effects of collagen peptides on exercise-induced gastrointestinal stress:a randomized, controlled trial. Eur J Nutr, 2022.
  • Jiang JX, Yu S, Huang QR, Zhang XL, Zhang CQ, Zhou JL, Prawitt J (2014) Agro Food Industry Hi Tech 25(2): 19-23
  • Wauquier F, Daneault A, Granel H, Prawitt J, Fabien-Soulé V, Berger J, Pereira B, Guicheux J, Rochefort GY, Meunier N, Blot A, Wittrant Y (2019), Nutrients 11(6): 1249
  • Robberechts, Ruben et al. “Partly substituting whey for collagen peptide supplementation improves neither indices of muscle damage nor recovery of functional capacity during eccentric exercise training in fit males.” International journal of sport nutrition and exercise metabolism, (2023), https://doi.org/10.1123/ijsnem.2023-0070
  • Newman, C., et al., Development of a mobile application to monitor the effectiveness of a hydrolyzed cartilage matrix supplement on joint discomfort: a real-life study. JMIR Form Res, 2023
  • 2014 Feb; 73(2): 376–384. Published online 2013 Jan 23. Randomised, controlled trial of avocado–soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study Emmanuel Maheu, Christian Cadet, Marc Marty, Dominique Moyse, Isabelle Kerloch, Philippe Coste, Maxime Dougados, Bernard Mazières, Tim D Spector, Hafid Halhol, Jean-Marie Grouin, Michel Lequesne

SUPPLEMENTATION

https://www.healthline.com/nutrition/african-mango#the-fruit | (1.A)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651880/
https://www.healthline.com/nutrition/l-carnitine#what-it-is | (2.A)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861661/pdf/1743-7075-7-30.pdf 
https://www.healthline.com/nutrition/alpha-lipoic-acid | (3.A)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022059/pdf/jcbn-48-26.pdf 
https://www.healthline.com/nutrition/12-proven-ashwagandha-benefits#1  | (4.A)
https://journals.sagepub.com/doi/pdf/10.1177/2156587216641830 
https://www.healthline.com/nutrition/berberine  | (5.A)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310165/pdf/ECAM2012-363845.pdf  |
(5.B) https://perfectketo.com/berberine-benefits/ 
https://www.healthline.com/nutrition/bioperine-and-piperine-supplement-benefits #1.-May-
increase-nutrient-absorption https://www.healthline.com/nutrition/chromium-picolinate  |
(7.A) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753428/pdf/dia.2007.0292.pdf 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570348/ 
https://www.healthline.com/nutrition/coenzyme-q10#TOC_TITLE_HDR_3  | (9.A)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112525/pdf/msy0005-0187.pdf 
https://www.healthline.com/nutrition/garcinia-cambogia-weight-los s | (10.A)
https://www.cochranelibrary.com/central/doi/10.1002/central/CN00515652/full  | (10.B)

https://www.redalyc.org/pdf/3092/309243321008.pdf 
https://www.today.com/health/green-coffee-bean-extract 
https://www.medicalnewstoday.com/articles/318611#research  | (11.A)
https://apjcn.nhri.org.tw/server/APJCN/26/6/1048.pdf  | (11.B)
https://apjcn.nhri.org.tw/server/APJCN/26/6/1048.pdf 
https://www.healthline.com/nutrition/10-benefits-of-green-tea-extract#The-Bottom-Line  |
(12.A) https://pubmed.ncbi.nlm.nih.gov/27634207/   | (12.B)
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.14176 
https://www.healthline.com/nutrition/guarana-benefits#TOC_TITLE_HDR_5  | (13.A)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490614/pdf/nutrients-09-00635.pdf 
https://www.healthline.com/nutrition/gymnema-sylvestre-benefits#TOC_TITLE_HDR_9  |
(14.A) https://www.researchgate.net/publication/221876373_An_EvidenceBased_System
atic_Review_of_Gymnema_Gymnema_sylvestre_R_Br_by_the_Natural_Standard_Rese
arch_Collaboration https://www.healthcareguys.com/2018/04/30/hordenine-your-
companion-in-weight-loss-and-some-weight-management-apps/   | (15.A)

https://medium.com/@liftmode/hordenine-benefits-top-3-effects-of-the-supplement-
derived-from-bitter-orange-37b1f26c0fcb  
https://www.psychologytoday.com/za/blog/sleep-newzzz/201708/what-you-need-know-
about-l-theanine | (16.A) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836118/
https://www.healthline.com/nutrition/manganese-benefits#TOC_TITLE_HDR_4 | (17. A)
https://link.springer.com/chapter/10.1007/978-1-4613-0723-5_15 
https://www.healthline.com/nutrition/nac-benefits#TOC_TITLE_HDR_4  | (18.A)
https://www.healthline.com/nutrition/nac-benefits#TOC_TITLE_HDR_8  | (18.B) https://minerva-access.unimelb.edu.au/bitstream/handle/11343/43874/Chemistry+and+biological_BBA+-
+General+Subjects.pdf;jsessionid=909997092D6AD7A953F92F5E2994C7B7?sequence
=1  https://www.ncbi.nlm.nih.gov/books/NBK542320/  | (19.A)
https://www.healthline.com/nutrition/iodine-deficiency-symptoms#TOC_TITLE_HDR_3 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272273  | (20.A)
https://naturalnewsblogs.com/rhodiola-miracle-cure-weight-loss-depression/  | (20.B)
https://www.tandfonline.com/doi/full/10.1080/13651501.2017.1417442 
https://www.healthline.com/nutrition/saffron#TOC_TITLE_HDR_7  | (21.A)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787332/ 
https://www.firstforwomen.com/posts/diet/selenium-weight-loss-174013  | (22.A)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307254/  | (22.B)
https://www.scielo.br/j/bjps/a/GZsSGmGVwZYrt9CVCfvShZt/?lang=en#